. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Nat Med. 2019 Jul 1;25(7):1096–1103. doi: 10.1038/s41591-019-0495-2

Extended data table 5. Frequency of occurrence of adverse events during the whole intervention period.

Frequency %	Placebo	Pasteurized Akk - 10¹⁰	Alive Akk - 10¹⁰	Ptotal	P1	P2
Nausea	0,792	1,341	0,468	0,196	0,726	0,653
Flatulence	0,907	2,788	0,709	0,319	0,436	0,798
Bloating	1,204	0,185	0,356	0,636	0,176	0,331
Cramps	2,104	0,477	0,96	0,375	0,065	0,256
Borborygmi	0,593	0,651	1,194	0,603	0,928	0,249
Gastric reflux	0,798	2,480	0,121	0,652	0,499	0,257

Compliance %	99,4	99,08	99,76	0,676	0,56	0,3

Values are expressed as the percentage of events occurring for adverse events (frequency) and as the percentage of days where the packages were correctly taken (compliance).

p_total : P-values from one-way ANOVA.

P1-2: P-values for comparison of Placebo groups versus Pasteurized group (P1) and versus Alive group (P2) with the two-tailed unpaired T-test, with p > 0,017 due to the Bonferroni adjustment.