Table 4.
Growth dynamics and symptom development during active monitoring stratified by baseline characteristics
| Factor | Mean/median AGR (cm3/year) | P | Mean/median RGR (%/year) | P | Symptom development, yes/total (%) | OR (95% CI) | MLR Pa | |
|---|---|---|---|---|---|---|---|---|
| Location | Non-skull base | 7.97/0.68 | 0.747 | 70.2/17.0 | 0.405 | 12/60 (20.0) | 0.116 | |
| Skull base | 5.82/2.93 | 28.1/17.2 | 5/25 (20.0) | |||||
| Diameter | ≥ 3.0 cm | 19.7/5.91 | 0.004 | 114/24.7 | 0.091 | 15/27 (55.5) | 12.16 (5.56–18.78) | < 0.001 |
| < 3.0 cm | 1.56/0.46 | 31.4/12.7 | 2/58 (3.45) | |||||
| Calcification | No | 19.0/19.0 | NA | 141/141 | NA | 1/1 (100) | ||
| Yes | NR | NR | NR | |||||
| Tumor signal intensity | Hyperintense | NR | NA | NR | NA | NR | ||
| Iso/hypointense | NR | NR | NR | |||||
| Peritumoral edema | Yes | NR | NA | NR | NA | NR | ||
| No | 2.32/0.62 | 19.7/13.2 | 1/29 (3.45) |
AGR absolute growth rate, RGR relative growth rate, MLR multi-level regression, NA not applicable, NR not reported
aPerformed to 50 iterations