. 2019 Aug 19;9:11981. doi: 10.1038/s41598-019-48418-4

Table 2.

Renal function parameters of baseline, at the time of AKI occurrence and CRRT initiation.

	Survivors n = 78 (49.4%)	Non-survivors n = 80 (50.6%)	P value
At acute kidney injury occurrence
Lactate (mmol/L)	4.9 (2.8, 9.8)	7.0 (3.7, 12.6)	0.113
BUN (mg/dL)	50.0 (30.5, 70.6)	40.5 (26.2, 57.5)	0.047
Creatinine (mg/dL)	2.54 (1.54, 3.66)	1.88 (1.27, 2.88)	0.003
Potassium (mmol/L)	4.7 (1.0, 5.8)	4.4 (3.7, 5.1)	0.024
Urine output (ml/day)	1,493 (505, 2,140)	1,114 (467, 2,487)	0.698
pH	7.295 (7.236, 7.389)	7.299 (7.209, 7.395)	0.963
GFR (ml/min/1.73 m^2¥)	24 (16, 39)	31 (19, 53)	0.020
GFR (ml/min/1.73 m^2€)	23 (15, 42)	32 (18, 57)	0.015
At ICU admission
Lactate (mmol/L)	3.4 (2.2, 5.6)	9.7 (4.4, 15.3)	<0.001
BUN (mg/dL)	44.0 (31.2, 65.7)	44.5 (31.9, 63.7)	0.836
Creatinine (mg/dL)	2.44 (1.45, 3.34)	2.34 (1.55, 3.07)	0.766
Potassium (mmol/L)	4.3 (3.6, 5.1)	4.3 (3.7, 5.0)	1.000
Urine output (ml/day)	585 (196, 1,381)	520 (188, 1,070)	0.321
pH	7.379 (7.306, 7.430)	7.300 (7.251, 7.374)	<0.001
At CRRT initiation
Lactate (mmol/L)	4.3 (2.6, 8.9)	7.5 (4.2, 15.5)	0.001
NGAL (ng/mL)	1,004 (465, 1,695)	820 (367, 2,083)	0.488
Cystatin C (mg/L)	2.76 (1.87, 3.89)	2.89 (2.04, 3.93)	0.640
GFR (ml/min/1.73 m^2≠)	14 (8, 28)	14 (8, 25)	0.829
Interval time from AKI to CRRT initiation (hours)	9 (6, 14)	26 (11, 66)	<0.001
CRRT duration (hours)	78 (52, 146)	67 (31, 212)	0.607

Values are expressed as n(%) or median(interquartile range) unless otherwise indicated; ^¥Estimated by MDRD equation; ^€Estimated by CKD-EPI creatinine equation; ^≠Estimated by CKD-EPI cystatin C equation.

AKI, Acute Kidney Injury; CRRT, continuous renal replacement therapy; BUN, blood urea nitrogen; GFR, Glomerular Filtration Rate; NGAL, Neutrophil Gelatinase-Associated Lipocalin; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.