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. 2019 Aug 19;9:12055. doi: 10.1038/s41598-019-48538-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of α4 integrin on circulating leukocytes in 3xTg-AD mice. Quantitative flow-cytometry analysis of peripheral CD4⁺ T cells (a), CD8⁺ T cells (b) and Ly6G⁺ cells (c) in 3xTg-AD mice (white bars) compared to wild-type control mice (WT ctrl) (black bars) at 6 and 9 months of age. For all cell populations, the graphs show the proportion of cells expressing α4 integrin and the mean fluorescence intensity (MFI) of normalized α4 integrin expression. Error bars represent SD (*P < 0.05, **P < 0.01, ***P < 0.001; Mann-Whitney U-test). At 6 months: n = 8 mice (3 F, 5 M) for the WT ctrl group; n = 7 mice (3 F, 4 M) for the 3xTg-AD group. At 9 months: n = 5 mice (2 F, 3 M) for the WT ctrl group and n = 8 mice (4 F, 4 M) for the 3xTg-AD group.