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. 2019 Aug 19;9:12064. doi: 10.1038/s41598-019-48590-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Structure of PS1145. (B) Effects of the small molecule kinase inhibitor PS1145 on cell viability in NPC and NP cell lines. The cell viability for all NPC cell lines were determined using the MTT assay (on day 3 after the treatment). (C) 2D CFA analysis of the effects of PS1145 on the colony-forming abilities of the selected NPC and NP cell lines. The bar chart shows the percentage of colony formation by each cell line treated with DMSO solvent control and PS1145. These experiments were conducted in triplicates. *p value < 0.05. Representative images of the CFA results are shown. (D) Apoptosis analysis of the effects of PS1145 in C666 cells treated. The TUNEL assay was used to detect the apoptotic cells on day 3 after the treatment with 32 μM PS1145. The bar chart shows the percentage of number of apoptotic cells formed after treatment with PS1145 or the solvent control (DMSO). *p value < 0.05.