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. 2019 Aug 19;9:12064. doi: 10.1038/s41598-019-48590-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo studies of the effects of PS1145 treatment on NPC cell lines (A) HONE1 and (B) C666. The cells were subcutaneously grafted on the right flank of nude mice. A total of 24 nude mice were used per cell line, with each group consisting of 12 mice. The mice with either treated with solvent control or PS1145 (3 mg/kg). The drug was administered bi-weekly via intravenous tail-vein injection. The average tumor sizes (upper panel) and average body weights (lower panel) of the animals were measured weekly. *p value < 0.05. Photos of tumor-bearing mice (injected with C666 cells) taken at the end of experiment.