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. 2019 Aug 19;9:12064. doi: 10.1038/s41598-019-48590-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Comparison of cell viability of C666 cells and its resistant derivative C666-PS1145R in response to PS1145 (4–64 μM). The cell viability was determined by MTT assay on day 3 after the treatment. The bar chart shows the percentage of number of viable cells treated with different concentrations of PS1145. *p value < 0.05. (B) Apoptosis analysis of the effects of PS1145 in C666 cells and its resistant cell line C666-PS1145R. The effects of 32 μM PS1145 on the formation of apoptotic cells of the parental C666 and its derivative C666-PS1145R were detected by TUNEL assay on day 3 after the treatment. The bar chart shows the percentage of number of apoptotic cells formed in the treatment with PS1145 or DMSO. *p value < 0.05. A parallel MTT assay was performed for the same batch of cell lines. (C) Western blot analysis of protein expression in C666 versus C666-PS1145 cells. The cytosolic and nuclei fractions of the proteins of interest were compared between the two cell lines. The p84 and GADPH are the nuclei and cytosol loading controls.