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. 2019 Aug 19;9:12059. doi: 10.1038/s41598-019-48557-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The proliferative cells are increased in p21 deficient mice. (a) Co-immunostaining with Anti-Ki67 (green) and Anti-E-Cadherin (red). Scale bar, 100 µm. (b) Quantification of the number of Ki67 positive cells. (c) The number of Ki67 positive cells on E-Cadherin stained area (Ki67 and E-Cadherin double stained cells). N = 3 different mice for each time points in each genotypes. (d) Co-immunostaining with Anti-p-H3^S10 (green) and Anti-Ki67 (red). Scale bar, 100 µm. (e) The number of p-H3^S10 and Ki67 double positive cells. (f) The ratio of p-H3^S10 per Ki67. Values were calculated by dividing the number of p-H3^S10 and Ki67 double positive cells by the number of Ki67. N = 3 different mice for each time points in each genotypes. Data are as given averages ± SD; *P < 0.05; **P < 0.01; NS, Not Significant (two-tailed unpaired Student’s t-test).