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. 2019 Aug 19;9:12009. doi: 10.1038/s41598-019-48519-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ephrin-A5 and Ephrin-B2 increase both intracellular and extracellular Neogenin IF. (a–q) Compared to MN media, ephrin-A5 100 ng/mL increases both intracellular and extracellular Neogenin IF in LMC growth cones (1.7 ± 0.2-fold, p = 0,005; 2.4 ± 0.4-fold, p = 0,004 respectively, N = 7). (b–q) Examples of growth cones quantified in (a). (r) A 20′ exposure to ephrin-A5, ephrin-B2 but not ephrin-A2 at 100 ng/mL increases intra. and extra. Neogenin IF in LMC growth cones (ephrin-A5 intra. Neogenin IF: 1.4 ± 0.1-fold, p = 0,006; ephrin-A5 extra. Neogenin IF: 2.3 ± 0.4-fold, p = 0.002; ephrin-A2 intra. Neogenin IF: 1.1 ± 0.1-fold, p = 0.06; ephrin-A2 extra. Neogenin IF: 1.9 ± 0.6-fold, p = 0.08; ephrin-B2 intra. Neogenin IF: 1.2 ± 0. 1-fold, p = 0.034; ephrin-B2 extra. Neogenin IF: 1.9 ± 0.3-fold, p = 0.015. N = 6. Data are shown as mean ± SEM, statistical significance was tested using a two-tailed (a) and one-tailed (r,s) unpaired sample t-test.