Table 3.
After PUFA-normalization arachidonic acid-derived oxylipids remain significantly associated with polyp type.
| Oxylipids | Age + Smoking | Age + Smoking + BMI | Age + Smoking + WC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | p-value | BHa p-value | Bona p-value | Beta | p-value | BH p-value | Bon p-value | Beta | p-value | BH p-value | Bon p-value | |
| 9-HODE | −0.03 | — | — | — | 0.03 | — | — | — | 0.01 | — | — | — |
| 13-HODE | −0.04 | — | — | — | 0.03 | — | — | — | 0.01 | — | — | — |
| Total HODE | −0.03 | — | — | — | 0.03 | — | — | — | 0.01 | — | — | — |
| 9-KODE | 0.06 | — | — | — | 0.19 | — | — | — | 0.15 | — | — | — |
| 13-KODE | 0.18 | — | — | — | 0.08 | — | — | — | 0.12 | — | — | — |
| Total KODE | 0.09 | — | — | — | 0.18 | — | — | — | 0.16 | — | — | — |
| 9,10-EpOME | 0.10 | — | — | — | 0.14 | — | — | — | 0.14 | — | — | — |
| 12,13-EpOME | −0.11 | — | — | — | 0.04 | — | — | — | 0.00 | — | — | — |
| Total EpOME | −0.07 | — | — | — | 0.07 | — | — | — | 0.04 | — | — | — |
| 9,10-DiHOME | −0.03 | — | — | — | 0.08 | — | — | — | 0.02 | — | — | — |
| 12,13-DiHOME | −0.02 | — | — | — | 0.15 | — | — | — | 0.08 | — | — | — |
| Total DiHOME | −0.03 | — | — | — | 0.10 | — | — | — | 0.04 | — | — | — |
| 5-HETE | 0.36 | p ≤ 0.0001 | p ≤ 0.005 | p ≤ 0.005 | 0.31 | p ≤ 0.001 | p ≤ 0.05 | p ≤ 0.05 | 0.32 | p ≤ 0.0005 | p ≤ 0.05 | p ≤ 0.05 |
| 11-HETE | 0.38 | p ≤ 0.0005 | p ≤ 0.005 | p ≤ 0.01 | 0.34 | p ≤ 0.005 | p ≤ 0.05 | p ≤ 0.05 | 0.35 | p ≤ 0.001 | p ≤ 0.05 | p ≤ 0.05 |
| 12-HETE | 0.25 | p ≤ 0.05 | — | — | 0.23 | p ≤ 0.05 | — | — | 0.24 | p ≤ 0.05 | — | — |
| 15-HETE | 0.28 | p ≤ 0.05 | — | — | 0.23 | 0.059 | — | — | 0.24 | p ≤ 0.05 | — | — |
| 20-HETE | 0.22 | — | — | — | 0.13 | — | — | — | 0.16 | — | — | — |
| Total HETE | 0.40 | p ≤ 0.005 | p ≤ 0.05 | p ≤ 0.05 | 0.35 | p ≤ 0.005 | 0.062 | — | 0.36 | p ≤ 0.005 | 0.054 | — |
| 14,15-EET | 0.10 | — | — | — | 0.08 | — | — | — | 0.07 | — | — | — |
| 8,9-DHET | 0.16 | — | — | — | 0.22 | — | — | — | 0.18 | — | — | — |
| 11,12-DHET | 0.22 | — | — | — | 0.30 | 0.064 | — | — | 0.27 | — | — | — |
| 14,15-DHET | 0.19 | — | — | — | 0.27 | — | — | — | 0.25 | — | — | — |
| Total DHET | 0.21 | — | — | — | 0.29 | — | — | — | 0.26 | — | — | — |
| AEA | −0.11 | — | — | — | −0.09 | — | — | — | −0.10 | — | — | — |
| 2-AG | −0.08 | — | — | — | −0.03 | — | — | — | −0.04 | — | — | — |
| LTB4 | 0.17 | — | — | — | 0.16 | — | — | — | 0.15 | — | — | — |
| PGE2 | 0.05 | — | — | — | 0.11 | — | — | — | 0.08 | — | — | — |
| TXB2 | 0.12 | — | — | — | 0.14 | — | — | — | 0.14 | — | — | — |
| 5,6-DiHETE | 0.10 | — | — | — | 0.11 | — | — | — | 0.10 | — | — | — |
| 17,18-DiHETE | −0.03 | — | — | — | 0.03 | — | — | — | 0.02 | — | — | — |
| Total DiHETE | 0.03 | — | — | — | 0.07 | — | — | — | 0.05 | — | — | — |
| 19,20-HDPA | −0.07 | — | — | — | 0.09 | — | — | — | 0.06 | — | — | — |
| DHEA | 0.14 | — | — | — | 0.15 | — | — | — | 0.15 | — | — | — |
| 9-KOHO | 0.14 | — | — | — | 0.19 | — | — | — | 0.17 | — | — | — |
| 13-KOHO | 0.30 | 0.079 | — | — | 0.12 | — | — | — | 0.17 | — | — | — |
| 9,10-DiEp | −0.02 | — | — | — | 0.06 | — | — | — | 0.02 | — | — | — |
| 12,13-DiEp | 0.06 | — | — | — | 0.14 | — | — | — | 0.10 | — | — | — |
| 14,15-DHEp | 0.06 | — | — | — | 0.20 | — | — | — | 0.17 | — | — | — |
Beta coefficients and p-values were determined through general linear regression with Poisson distribution. Models were defined as Polyp type = Age + Smoking + log(oxylipid/PUFA), Polyp type = Age + Smoking + BMI + log(oxylipid/PUFA), and Polyp type = Age + Smoking + WC + log(oxylipid/PUFA). P-values were adjusted for false discovery rate (FDR) according to Benjamini-Hochberg and Bonferroni. Only p-values < 0.1 are displayed. Oxylipids totals calculated as follows: Total HODE = Σ 9-HODE + 13-HODE; Total KODE = Σ 9-KODE + 13-KODE; Total EpOME = Σ 9,10-EpOME + 12,13-EpOME; Total HETE = Σ 5-HETE + 11-HETE + 12-HETE + 15-HETE + 20-HETE; Total DHET = Σ 8,9-DHET + 11,12-DHET + 14,15-DHET; Total DiHETE = Σ 5,6-DiHETE + 17,18-DiHETE.