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. 2019 Aug 19;9:11990. doi: 10.1038/s41598-019-48317-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hemophagocytosis and affected lymphatic nodules in the GI system of a fatal cat at 8 dpi with SFTSV and normal structures of surviving cat No. 1. (A,B) Normal aggregated lymphatic nodules in the lamina propria of the stomach of cat No. 1. SFTSV-NP-positive cells are not found. (C) Aggregated lymphatic nodules (*) in the lamina propria of the junction of pyloric gland region and duodenum. Decreased lymphocytes, necrotic germinal centers, congestion and missing nodule-associated epithelium (arrow) are seen in the lesions grossly identified as red spots in the stomach (in Fig. 8E). The villi are intact. St, stomach; Duo, duodenum; BrG, Brünner’s gland. (D) The lesional area was positive for SFTSV-NP. (E,F) Normal structure of the jejunum of cat No. 1. There are not found SFTSV-NP-positive cells. (G,H) Peyer’s patches in the jejunum. Necrotizing large sac-like lymphatic nodules (*) are positive for SFTSV-NP, while the internodular regions (IN) and villi are intact. Hemorrhaging occurred within the capsule of a nodule (red arrow). (I–L) Normal structures of surviving cat No. 1. I, sternal bone marrow; (J), mesenteric lymph node; (K,L), liver. (M) Hemophagocytosis in the sternal bone marrow from cat No. 2. Many hemophagocytic macrophages are present in the vascular space (arrowheads). (N) A mesenteric lymph node from cat No. 3. Numerous hemophagocytes are present in the medullary sinus. (O) Liver from cat No. 2. A large number of hemophagocytic macrophages (Kupffer cells, arrowheads) and round-shaped mononuclear cells (arrows) are seen in the sinusoids. (P) They are positive for SFTSV-NP (SFTSV-NP). The hepatocytes seem to be normal. (A,C,E,G,I–O); H&E staining, (C,D,F,H,P); SFTSV-NP, viral antigen by immunohistochemistry. Bars, (A–H), 1 mm, (I,K–M,O,P), 20 µm; (J,N), 100 µm.