TABLE 1.
Minimal inhibitory concentration summary of nemonoxacin and comparator agents against M. pneumoniae.
| Isolates and reference strains | M. pneumoniae (n = 50)a | ATCC 29342 | MIC (μg/ml)b | |||
| MIC range | MIC50 | MIC90 | MIC | S | R | |
| Antimicrobial agents (μg/ml) | ||||||
| Nemonoxacin | 0.03 to 0.25 | 0.125 | 0.25 | 0.125 | − | − |
| Moxifloxacin | 0.015 to 0.25 | 0.125 | 0.25 | 0.25 | ≤0.05 | − |
| Levofloxacin | 0.03 to 1 | 0.5 | 0.5 | 0.25 | ≤1 | − |
| Ciprofloxacin | 0.03 to 2 | 1 | 2 | 0.25 | − | − |
| Tetracycline | 0.06 to 2 | 0.25 | 0.5 | 0.5 | ≤2 | − |
| Minocycline | 0.03 to 2 | 0.25 | 0.5 | 0.5 | − | − |
| Doxycycline | 0.015 to 2 | 0.5 | 0.5 | 0.25 | − | − |
| Erythromycin | 0.0075 to >128 | >128 | >128 | 0.0075 | ≤0.5 | ≥1 |
| Roxithromycin | ≤0.00375 to >128 | 64 | >128 | 0.03 | − | − |
| Azithromycin | ≤0.00375 to 64 | 8 | 32 | 0.0075 | ≤0.5 | ≥1 |
| Josamycine | ≤0.00375 to 32 | 2 | 4 | 0.03 | − | − |
aIncludes 48 M. pneumoniae type I and 2 M. pneumoniae type II organisms, and 46 macrolide-resistant organisms; bInterpretive criteria from CLSI M43-A. S, susceptible; R, resistant.