TABLE 2.
Minimal inhibitory concentration summary of nemonoxacin and comparator agents against M. hominis.
| Isolates and reference strains | M. hominis (n = 20)a | ATCC 23114 | MIC (μg/ml)b | |||
| Range | MIC50 | MIC90 | MIC | S | R | |
| Antimicrobial agents (μg/ml) | ||||||
| Nemonoxacin | 0.25 to 8 | 2 | 8 | 0.25 | − | − |
| Moxifloxacin | 0.06 to 8 | 0.5 | 8 | 0.125 | ≤0.25 | ≥0.5 |
| Levofloxacin | 0.25 to 16 | 4 | 8 | 0.5 | ≤1 | ≥2 |
| Ciprofloxacin | 0.5 to >16 | 4 | 16 | 1 | − | − |
| Tetracycline | 0.03 to 0.125 | 0.06 | 0.06 | 0.06 | ≤4 | ≥8 |
| Minocycline | ≤0.0075 to 0.015 | 0.0075 | 0.0075 | ≤0.0075 | − | − |
| Doxycycline | ≤0.0075 to 0.03 | 0.0075 | 0.0075 | ≤0.0075 | − | − |
| Erythromycin | >128 | >128 | >128 | >128 | − | − |
| Roxithromycin | >128 | >128 | >128 | >128 | − | − |
| Azithromycin | 64 to >128 | >128 | >128 | >128 | − | − |
| Josamycine | 0.125 to 1 | 0.5 | 0.5 | 0.5 | − | − |
aIncludes 16 fluoroquinolone-resistant organisms; bInterpretive criteria from CLSI M43-A. S, susceptible; R, resistant.