TABLE 4.
Minimal inhibitory concentration summary for nemonoxacin and the comparator agents.
| Isolates and reference strains | Ureaplasma spp. (n = 77) | ATCC 33175 | MIC (μg/ml)c | |||
| Range | MIC 50 | MIC 90 | MIC | S | R | |
| Antimicrobial agents (μg/ml)a | ||||||
| Nemonoxacin | 0.06 to 8 | 1 | 2 | 0.5 | − | − |
| Moxifloxacin | 0.125 to 8 | 0.5 | 1 | 0.5 | ≤2 | ≥4 |
| Levofloxacin | 0.25 to 16 | 2 | 2 | 0.5 | ≤2 | ≥4 |
| Tetracycline | 0.015 to 0.25 | 0.125 | 0.25 | 8 | ≤1 | ≥2 |
| Minocycline | ≤0.0075 to 0.06 | 0.015 | 0.06 | 0.25 | − | − |
| Doxycycline | ≤0.0075 to 0.125 | 0.03 | 0.06 | 0.5 | − | − |
| Erythromycin | 0.25 to 2 | 1 | 1 | 1 | ≤8 | ≥16 |
| Roxithromycin | 0.125 to 1 | 0.25 | 0.5 | 0.25 | − | − |
| Azithromycin | 0.125 to 1 | 0.5 | 1 | 0.5 | − | − |
| Josamycine | 0.03 to 0.5 | 0.125 | 0.25 | 0.5 | − | − |
| Antimicrobial agents (μg/ml)b | ||||||
| Nemonoxacin | 0.25 to >16 | 2 | 8 | 0.5 | − | − |
| Moxifloxacin | 0.125 to 8 | 4 | 4 | 0.5 | ≤2 | ≥4 |
| Levofloxacin | 0.5 to 16 | 4 | 8 | 0.5 | ≤2 | ≥4 |
| Tetracycline | 0.25 to >16 | 0.5 | 1 | 8 | ≤1 | ≥2 |
| Minocycline | 0.03 to 4 | 0.125 | 0.25 | 0.25 | − | − |
| Doxycycline | 0.06 to 8 | 0.125 | 0.25 | 0.5 | − | − |
| Erythromycin | 0.25 to 4 | 1 | 4 | 1 | ≤8 | ≥16 |
| Roxithromycin | 0.125 to 2 | 0.25 | 1 | 0.25 | − | − |
| Azithromycin | 0.125 to 4 | 0.5 | 2 | 0.5 | − | − |
| Josamycine | 0.015 to 1 | 0.125 | 0.25 | 0.5 | − | − |
aTotal of 64 U. parvum, including two fluoroquinolone-resistant organisms; bTotal of 13 U. urealyticum, including eight fluoroquinolone-resistant and one tetracycline-resistant organisms; cInterpretive criteria from CLSI M43-A. S, susceptible; R, resistant.