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. 2019 Aug 13;9:754. doi: 10.3389/fonc.2019.00754

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Copyright © 2019 Sun, Wang, Gai, Guan, Li, Li, Zhao, Zhao, Fu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT5 expression is increased in ovarian cancer tissues and high SIRT5 level predicts poor chemo-response. (A) The mRNA expression of Sirtuins in patients with ovarian cancer (GEPIA). (B) Immunohistochemical staining results of SIRT5 expression in 90 cases ovarian cancer tissues and 10 cases normal tissues microarrays. (C) Representative immunohistochemical staining images of SIRT5 expression (positive or negative) in ovarian cancer and normal tissues. (Magnification, × 400; Scale bar = 20 μm). (D) High SIRT5 level predicts poor progression-free survival (PFS) by online Kaplan-Meier analysis. ^**P < 0.01.