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. 2019 Aug 13;10:1926. doi: 10.3389/fimmu.2019.01926

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Copyright © 2019 Vranjkovic, Deonarine, Kaka, Angel, Cooper and Crawley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evidence of increased degranulation is observed in circulating naïve CD8⁺ T-cells in HCV-infected individuals with advanced liver fibrosis while l-EM cells reduced their capacity to degranulate. The detection of CD107a, a marker of cell degranulation, was conducted by flow cytometry on anti-CD3/-CD28-stimulated CD8⁺ T-cells isolated from the blood of health controls and HCV⁺ individuals with minimal or advanced liver fibrosis. (A) The proportion of CD107a⁺ cells are summarized in a bar graph, by cell subset. Statistically significant changes are demonstrated with representative dot plots to compare CD107a expression in HCV-infected individuals with either minimal or advanced liver fibrosis in (B,C) naïve and (D,E) l-EM cell subsets. Statistically significant changes are indicated with a “^*” (one-way ANOVA and Dunnett's post-test, p ≤ 0.05).