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. 2019 Aug 12;11:7605–7618. doi: 10.2147/CMAR.S212069

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© 2019 Grywalska et al.

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Time to lymphocyte doubling in patients with chronic lymphocytic leukaemia and detectable [EBV(+)] vs undetectable [EBV(−)] EBV DNA (A) and high or low expression of PD-1 on CD4+, CD8+, and CD19+ cells and in serum (B–E). The classification of PD-1 expression as high or low was based on medians specific for EBV(+) and EBV(−) patients. P-values for log-rank tests are presented for comparisons between EBV(+) and EBV(−) patients (A) and between patients with high or low PD-1 expression within the groups of EBV(+) and EBV(-) patients (B–E). p-values are for log-rank tests, adjusted with Holm’s correction, comparisons between patients with high or low expression within the EBV(−) or EBV(+) groups.

Abbreviations: EBV, Epstein-Barr virus; PD1, programmed cell death protein 1, EBV(−), patients without detectable EBV DNA; EBV(+), patients with detectable EBV DNA; low, expression below median within the EBV(−) or EBV(+) groups; high, expression above median within the EBV(−) or EBV(+) groups.