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. 2019 Jul 17;17:688–700. doi: 10.1016/j.omtn.2019.07.003

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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SL Interactions Suggest New Therapeutic Strategy

(A) Network of potential anti-cancer therapies. Ellipse nodes represent genes, and the gene alteration rates in the specific cancer types are shown below the gene symbols. Capsules represent drugs. The black lines between capsules and ellipse node depict drug-target relationship. The edge colors represent the cancer types within which the synthetic lethal interactions were detected. (B) Breast cancer cell lines with LAMP1 amplifications had significantly lower GI50 of paclitaxel than breast cancer cell lines with wild-type LAMP1 (p = 0.02, Wilcoxon rank-sum test). (C) Knockout of TUBB3 by CRISPR in cancer cells with LAMP1 amplification showed better survival than cells with wild-type LAMP1 (p = 0.006, Wilcoxon rank-sum test).