Table 2.

Behavioral results for three participant groups.

	Control	Premanifest	Manifest	P
LARS-s % clinically relevanta	−9.90 ± 3.1, N = 31 12.9%	−8.65 ± 4.1, N = 17 29.4%	−6.14 ± 5.4, N = 21 52.2%	.009⁎
Cognitive apathyb	−4.29 ± 1.8	−4.24 ± 1.9	−2.76 ± 3.2	.050
Auto-activation deficitb	−2.36 ± 1.2	−1.00 ± 2.2	−0.86 ± 2.3	.008⁎
Emotional apathyb	−3.16 ± 0.90	−3.12 ± 1.2	−2.95 ± 1.3	.279
PBA-s, apathyc	-	4.76 ± 8.6, N = 21	8.08 ± 7.6, N = 24	-
PBA-s, affectivec	-	4.91 ± 5.9	2.63 ± 3.29	-

Data presented as mean ± standard deviation. Greater or more positive numbers indicate more severe behavioral symptoms. P-values refer to one-way ANOVA between controls, premanifest, and manifest groups.

N = number of participants; LARS-s = Lille Apathy Rating Scale, short-from; PBA-s = Problem Behavior Assessment, short-form.

^⁎P-values retained significance after false discovery rate correction (q = 0.05).

^aCut-off for clinically relevant global apathetic syndromes is defined as a total LARS-s score > −7 (Dujardin et al., 2013).

^bSubscale computed from the LARS-s.

^cMeasured based on ‘apathy’ and ‘affective behavior’ components of factor analysis in Callaghan et al. (2015).