Varying the ion channel current densities. The figures to the left correspond to the activation thresholds estimates by the computational model for the Aδ model when the pin electrode is activating the nerve model. The activation thresholds were calculated when the fiber model was placed underneath the electrode in the middle of the epidermis (Aδ model) or dermis (Aβ model). For the Aδ model, the NaP and KA currents were reduced to 10% of their original value. The HCN current and the NaTTXs current were increased by factors of 2 and 8, respectively. The figures to the right correspond to the activation thresholds estimated by the computational model for the Aβ model when the patch electrode is activating the nerve model. For the Aβ model, the HCN current was reduced to 10% of its original value, and the NaP density was increased by a factor of 1.5. To see this figure in color, go online.