Table 2.

Processes modulated by G protein-coupled estrogen receptor and their importance in neoplastic transformation of the colon

Features of cancer cells	Process	Anti-tumorigenic	Pro-tumorigenic	Ref.
Proliferation and tumor growth	Apoptosis	Yes	No	[73]
	Cell cycle	Yes	No	[73]
	DNA repair	No	Yes	[64]
	Endoplasmic reticulum stress	Yes	No	[73]
	Estrogen metabolism	No	Yes	[90,91]
	Mitochondrial membrane polarity	Yes	No	[73]
	Oxygen level	Yes under normoxia	Yes under hypoxia	[64]
Migration	Fatty acid metabolism	No	Yes	[107]
	Oxygen level	Yes under normoxia	Yes under hypoxia	[64]