Table 4.
Detailed outcomes of 29 patients on no immunosuppressive therapy for mild Crohn’s disease
| Year (age) of diagnosis | Duration of followup after initial 2 yr of treatment (mo) | Followup colonoscopy histology findings | Medications | Outcome/ complications |
| 2002 (10 yr) | 111 | 2007-normal colonoscopy | 5-ASA (Asacol), prednisone | Escalation to 6MP(age 20) Surgery for ileal stricture (age 22) |
| 2004 (12 yr) | 49 | 2009-Noncaseating granulomas in TI and throughout colon. | 5-ASA (Pentasa, Lialda) | Stayed on ASA, no escalation |
| 2001 (9 yr) | 32 | Not done | 5-ASA, prednisone | Stayed on ASA, no prednisone after induction, no escalation |
| 2002 (10 yr) | 131 | 2009- chronic active ileitis with ulceration | 5-ASA (Pentasa, Lialda) | 2015-escalation to mercaptopurine, then adalimumab |
| 2003 (10 yr) | 66 | 2010-severely active ileitis | 5-ASA (Pentasa), 3 courses of prednisone over 3 years | 2012-began mercaptopurine |
| 2005 (13 yr) | 15 | Not done | 5-ASA (Asacol) | Ileal phlegmon, treated with antibiotics and subsequent mercaptopurine |
| 2010 (16 yr) | 43 | 2014-nonnecrotizing granuloma throughout the colon | 5-ASA (Asacol) | Stayed on ASA, no escalation. |
| 2010 (16 yr) | 1 | Not done | 5-ASA (Asacol), hydrocortisone | Stayed on ASA, no steroid after initial induction |
| 2008 (14 yr) | 63 | 2010-mild active ileitis colitis in ascending and sigmoid colon | 5-ASA (Asacol), metronidazole | Stayed on ASA, no escalation |
| 2012 (17 yr) | 7 | 2014-nonnecrotizing granulomas in left colon | 5-ASA (Pentasa) | Escalation to mercaptopurine, then adalimumab |
| 2008 (14 yr) | 65 | 2012-normal ileum, chronic active colitis 2016-normal colonoscopy | 5-ASA (Pentasa), budesonide | No escalation |
| 2008 (13 yr) | 47 | 2014-mild active colitis, in ascending, granuloma in ileum | 5-ASA (Pentasa), metronidazole | 6MP initiated |
| 2007 (12 yr) | 71 | 2016-Inactive colitis at IC valve | 5-ASA (Asacol) | Ileal stricture in 2016, no surgery yet |
| 2008 (13 yr) | 21 | 2009-active colitis in cecum, inactive in remainder of colon | 5-ASA (Pentasa, Lialda) | Discontinued all therapy, never hospitalized |
| 2005 (10 yr) | 14 | None prior to escalation | 5-ASA (Pentasa), metronidazole | 6MP, then infliximab |
| 2010 (15 yr) | 6 | None | 5-ASA (Pentasa), prednisone induction | No escalation |
| 2005 (9 yr) | 85 | 2013-focal mild ileitis | 5-ASA (Pentasa), metronidazole | No escalation |
| 2000 (4 yr) | 1 | Not done | Sulfasalazine, flagyl | Begun infliximab for colonic and perianal disease |
| 2002 (12 yr) | 38 | 2012-normal colonoscopy | 5-ASA (mesalamine), prednisone | No escalation |
| 2006 (9 yr) | 87 | 2016-chronic active colitis, non- necrotizing granuloma in transverse colon | 5-ASA (Pentasa), two courses of steroids in first two years | No escalation |
| 2002 (4 yr) | 136 | 2010-mild active colitis | Sulfasalazine, budesonide | No escalation |
| 2001 (3 yr) | 100 | Not done | Sulfasalazine, budesonide | No escalation |
| 2003 (5 yr) | 118 | 2012-focal moderately active colitis | Sulfasalazine, prednisone | No escalation |
| 2009 (10 yr) | 41 | 2014-focal acute inflammation | 5ASA (Asacol), Budesonide | No escalation |
| 2005 (7 yr) | 99 | 2014-mildly active colitis | Pentasa | No escalation |
| 2007 (6 yr) | 97 | 2013- chronic inactive colitis | Pentasa, Sulfasalazine | No escalation |
| 2012 (10 yr) | 16 | 2013-mild active colitis with granulomata | Asacol, prednisone induction | No escalation |
| 2008 (3 yr) | 54 | Not done | Sulfasalazine, probiotics | No escalation |
| 2010 (3 yr) | 11 | 2012-chronic moderately active colitis | Sulfasalazine, prednisone induction | No escalation |