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. 2019 Aug 14;25(30):4074–4091. doi: 10.3748/wjg.v25.i30.4074

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Differentially expressed proteins in normal and liver disease states. Heat maps of differentially expressed proteins (DEPs) (truncated) that were selected following supervised analysis (A) Normal vs. Cirrhosis, (B) Normal vs. Hepatocellular carcinoma, (C) Cirrhosis vs. Hepatocellular carcinoma, and (D) Venn Diagram comparing the significantly DEPs identified. (E) Interactive Network Analysis of DEPs in cirrhosis and hepatocellular carcinoma as compared to normal shows HNF4α as a focus hub to many DEPs. (F) A representative of immunoblot analysis of TF and APOA1 (upper panel), HNF4α (lower panel) in tissue samples of AA & CA. GAPDH was used as a loading control, as published in[23].