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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Cell Rep. 2019 Jun 25;27(13):3832–3843.e6. doi: 10.1016/j.celrep.2019.05.088

Figure 1. Astrocytic differentiation was impaired in SCZ GPCs.

Figure 1

A–D, At the neural progenitor cell (NPC) stage, both SCZ and CTR (4 distinct patients and derived lines each, n ≥ 3/each line) hNPCs highly expressed both SOX1 and PAX6. E–G, Similarly, the efficiency of PDGFRA/CD140a-defined hGPC generation did not differ between SCZ and CTR lines (4 different patient-specific lines each, n ≥ 3/each line). H–J, In contrast, the proportion of GFAP+ astrocytes was significantly higher in CTR lines (4 CTR lines, n ≥ 3/each line [70.1 ± 2.4%]) vs. SCZ lines (4 SCZ lines, n ≥ 3/each line, [39.9 ± 2.0%]).

Scale: 50 μm; ***p<0.001 by two tailed t-test; NS: not significant; mean ± SEM.