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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Cell Rep. 2019 Jun 25;27(13):3832–3843.e6. doi: 10.1016/j.celrep.2019.05.088

Figure 2. BAMBI expression in normal hGPCs phenocopied the glial differentiation defect of SCZ.

Figure 2

A–B, Overexpression of the membrane-bound BMP antagonist BAMBI in CTR hGPCs (4 CTR lines, 3 repeats/each line) significantly decreased their efficiency of astrocytic transition. B, However, BAMBI knockdown in SCZ hGPCs (4 SCZ lines, 3 repeats/each line) was not sufficient to restore astrocytic differentiation. C, Besides BAMBI, the BMP antagonists follistatin (FST) and gremlin1 (GREM1) were also upregulated in SCZ hGPCs, relative to controls. Scale: 50 μm; ***p<0.001, 1-way ANOVA for B; **P<0.001 by 2-tailed t-test for C; NS: not significant; mean ± SEM.