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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Pharm Res. 2018 Jul 12;35(9):177. doi: 10.1007/s11095-018-2455-9

Table I.

Incidence Rate of Brain Metastases

Primary site Incidence Rates References
Lung (overall) 16.3–19.9% (17,18)
 SCLC* 29.7% (at 5 years) (17,18)
 NSCLC* 12.6% (at 5 years) (17,18)
Breast 10–15% (17,18)
 HER2 positive 25–50% (162)
 Triple negative 20% (162)
Melanoma 6.9–7.4% (17)
Renal 6.5–9.8% (17)
Colorectal 3.0% (17)
*

can be up to 50–60% depending on study and disease duration (22,23)