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. 2019 Aug 19;17:272. doi: 10.1186/s12967-019-2007-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Age-dependent response to RCF. a Principal component analysis (PCA) of the biomarkers tested in the study for the three time points and similar analysis performed in young (n = 37, 26.5 ± 3.2 years, 20–30) and older participants (n = 41, 68.1 ± 8.6 years, 52–85). b Age-related adaptations to fasting and c the benefits of fasting on CRP and systolic BP were tested after stratification based on age [young (20–30), middle-aged (50–64) and old (65–85)]. d Similar analysis as in c showing IL-6, d-dimer and OPG. ^ap = 0.005 significant difference with pre-fasting 65–85 (no difference with all groups together). ^bp = 0.03 significant difference with pre-fasting 65–85 (no difference with all groups together)