Table 3.
Univariate and Multivariable Cox Proportional Hazard Models of OS vs BMI
| anti-CTLA-4 | anti-PD-1 | Combination | |||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | ||
| Univariate Model | Overweight (vs Normal BMI) | 1.05(0.61,1.8) | 0.86 | 1.29(0.7,2.36) | 0.42 | 0.69(0.29,1.62) | 0.39 |
| Obesity (vs Normal BMI) | 1.07(0.63,1.8) | 0.81 | 0.88(0.42,1.85) | 0.74 | 0.57(0.19,1.73) | 0.32 | |
| Multivariable Model | Overweight (vs Normal BMI) | 0.83(0.47,1.47) | 0.52 | 1.6(0.86,2.96) | 0.14 | 0.7(0.2,2.47) | 0.58 |
| Obesity (vs Normal BMI) | 1.22(0.75,2) | 0.42 | 1.04(0.48,2.24) | 0.92 | 0.92(0.24,3.49) | 0.9 | |
| Female | 0.73(0.45,1.18) | 0.19 | 0.43(0.24,0.78) | 0.01 | 1.18(0.48,2.92) | 0.72 | |
| Age at Treatment Initiation | 1.01(0.99,1.02) | 0.2 | 1.01(0.98,1.03) | 0.61 | 1.01(0.98,1.04) | 0.66 | |
| Stage IV at Treatment Initiation(vs Stage III) | 15.76(2.12,117.24) | 0.01 | 1.07(0.38,2.98) | 0.9 | 1.12(0.1,12.97) | 0.93 | |
| ECOG Status | 2.23(1.62,3.07) | <.001 | 2.92(1.88,4.51) | <.001 | 2.45(1.47,4.1) | 0.001 | |
| LDH High | 1.62(1.05,2.5) | 0.03 | 2.35(1.27,4.35) | 0.01 | 2.48(0.9,6.85) | 0.08 | |
| Number of Metastatic Sites | 1.2(1,1.44) | 0.06 | 1.16(0.97,1.38) | 0.1 | 0.85(0.58,1.24) | 0.4 | |
| BRAF Mutated | 0.99(0.53,1.85) | 0.96 | 0.78(0.25,2.48) | 0.68 | 0.78(0.19,3.16) | 0.73 | |