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. 2019 Aug 19;16:169. doi: 10.1186/s12974-019-1527-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Characterization of DE genes in CD11b+CD45^lo and CD11b+CD45^hi cells of CD and WD-fed mice. a Principal component analysis (PCA) plot showing the first and second component of transcriptional expression profiles between CD11b+CD45^lo and CD11b+CD45^hi cells. b–d Box plots showing the gene expression in log₂-transformed cpm in CD11b+CD45^lo and CD11b+CD45^hi cells from both CD and WD-fed mice. b Expression of marker genes of microglia, monocytes/macrophage, and granulocytes. c Expression of disease-associated microglia (DAM) genes. d Expression of complement cascade genes