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. 2019 Aug 20;17:99. doi: 10.1186/s12964-019-0412-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Schematic diagram of estrogen-Gln metabolism in estrogen-sensitive UECC. For estrogen-sensitive UEC, estrogen remarkably increases GLS and activates glutamine metabolism through up-regulating c-MYC. These processes remarkably lead to enhanced cell viability and decreased autophagy of estrogen-sensitive UECC. The GLS inhibitor CB-839 restricts the effects of estrogen on UECC’s growth and autophagy by inhibiting Gln metabolism