Table 1.

Genes significantly associated with risk of multiple myeloma

Locus	Gene	P value	N/Nindep	Z-score min	Z-score max	Z-score mean	Z-score s.d.	SNP adjusting for	P value after SNP adjustment
16p11.2	QPRT	1.01 × 10−7	17/8	− 2.73	3.04	− 0.59	1.63	rs13338946	0.15
16p11.2	RNF40	4.02 × 10−7	24/3	0.05	5.68	4.67	1.48	rs13338946	0.89
16p11.2	PRR14	4.28 × 10−7	2/2	− 5.38	− 0.20	− 2.79	3.66	rs13338946	0.34
16p11.2	C16orf93	8.07 × 10−7	13/5	− 5.74	− 0.34	− 4.59	1.73	rs13338946	0.24
16p11.2	RP11-2C24.5	1.54 × 10−6	5/5	− 5.64	4.43	− 0.58	3.80	rs13338946	0.73
16p11.2	PRSS53	1.71 × 10−6	16/8	− 5.19	3.68	− 1.04	2.71	rs13338946	0.79
16q23.1	RFWD3	7.71 × 10−7	34/7	− 3.41	6.35	2.51	3.26	rs7193541	0.47
17p11.2	TBC1D27	1.95 × 10−13	6/6	− 1.91	4.19	0.51	2.16	rs34562254	0.89
17p11.2	USP32P1	4.88 × 10− 13	3/3	− 7.29	2.80	−1.36	5.27	rs34562254	0.01
17p11.2	PEMT	5.65 × 10−8	14/7	− 1.74	5.43	1.36	1.93	rs34562254	0.01
22q13.1	APOBEC3C	1.10 × 10−18	21/8	− 8.93	0.24	− 4.09	2.21	rs139402	0.13
22q13.1	APOBEC3H	4.28 × 10−15	7/5	− 5.45	7.92	− 0.95	4.38	rs139402	0.76
22q13.1	FAM83F	4.65 × 10−10	11/8	− 4.25	2.56	− 0.48	2.01	rs139402	1.1 × 10−4
22q13.1	APOBEC3D	6.2 × 10−10	29/7	− 8.38	− 0.85	− 4.15	1.56	rs139402	0.04
22q13.1	APOBEC3F	5.15 × 10−9	5/4	− 6.34	6.15	1.09	5.07	rs139402	0.13
22q13.1	APOBEC3G	1.81 × 10−7	43/2	0.36	6.57	4.94	1.17	rs139402	0.17
2p23.3	KIF3C	1.65 × 10−18	6/6	− 9.40	4.35	− 1.19	4.50	rs7577599	1.4 × 10−9
2p23.3	EPT1	8.37 × 10−16	9/9	− 1.76	6.00	1.30	2.72	rs7577599	2.1 × 10−5
2p23.3	CENPO	1.48 × 10−13	12/8	− 6.60	2.22	− 0.05	2.57	rs7577599	6.1 × 10−8
2p23.3	DNMT3A	2.44 × 10−13	8/8	− 2.89	7.96	1.94	3.07	rs7577599	0.01
2p23.3	AC010150.1	2.90 × 10−13	4/4	− 0.88	7.89	1.61	4.20	rs7577599	8.9 × 10−10
2p23.3	PTGES3P2	4.46 × 10−11	7/5	− 4.23	2.03	− 2.46	2.08	rs7577599	1.1 × 10−4
2p23.3	DTNB	1.16 × 10−7	11/10	− 3.88	5.78	0.36	2.38	rs7577599	3.1 × 10−3
2p23.3	DNAJC27	1.74 × 10−7	8/8	− 0.74	4.52	1.95	1.58	rs7577599	0.11
3p22.1	ULK4	9.01 × 10−15	43/6	0.90	8.89	6.60	2.24	rs6599192	0.85
3q26.2	MYNN	7.84 × 10−13	6/6	− 7.91	1.58	− 1.66	3.32	rs10936600	0.17
3q26.2	LRRIQ4	9.63 × 10−9	3/2	− 5.94	− 0.88	− 4.25	2.92	rs10936600	0.03
3q26.2	LRRC34	3.35 × 10−8	21/2	3.97	6.47	5.12	0.66	rs10936600	0.82
3q26.2	ACTRT3	4.28 × 10−7	4/4	− 0.94	5.80	1.56	2.94	rs10936600	0.48
6q21	ATG5	1.55 × 10−12	4/4	0.93	5.89	3.72	2.41	rs9372120	0.07
7p15.3	CDCA7L	9.61 × 10−9	8/8	− 3.11	4.61	1.12	2.42	rs75341503	0.23
7q36.1	CHPF2	2.53 × 10−7	6/6	− 2.01	2.13	0.40	1.49	rs7781265	0.06

Excludes associations found in the HLA region. s.d., standard deviation. Detailed are the S-MultiXcan P values for association between gene expression MM, and the corresponding Z-scores quantifying this relationship (e.g. a positive score indicates increased gene expression increases risk). N and N_indep indicate the total number of single-tissue results used for S-MultiXcan analysis and the number of independent components after singular value decomposition, respectively