Table 2.
Genotype and allele frequencies of the XKR6 rs7819412 SNP in cases and controls [n (%)]
| Genotype/ Allele |
Control (n = 643) |
CAD (n = 588) |
Ischemic stroke (n = 552) |
CAD | Ischemic stroke | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | ||||
| GG | 551 (85.7) | 476 (81.0) | 447 (81.2) | 1 | 1 | ||
| GA/AA | 92 (14.3) | 112 (19.0) | 105 (18.8) | 1.409 (1.042–1.906) | 0.026 | 1.407 (1.036–1.911) | 0.029 |
| x 2 | 0.576 | 0.197 | 0.052 | ||||
| HWE (P) | 0.448 | 0.657 | 0.820 | ||||
| x 2 | 4.991 | 4.794 | |||||
| P | 0.025 | 0.029 | |||||
| G | 1189 (92.5) | 1057 (89.9) | 994 (90.0) | 1 | 1 | ||
| A | 97 (7.5) | 119 (10.1) | 110 (10.0) | 1.380 (1.042–1.827) | 0.024 | 1.356 (1.019–1.805) | 0.036 |
| x 2 | 5.094 | 4.401 | |||||
| P | 0.024 | 0.036 | |||||
Adjusted for sex, age, smoking, drinking, BMI, diabetes, Mean arterial pressure, hyperlipidemia. CAD coronary artery disease