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. 2019 Aug 20;38:364. doi: 10.1186/s13046-019-1372-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a CYT levels were significantly lower in the COAD and READ datasets compared to the normal colon and rectum, respectively. b GZMA and PRF1 proteins were lowly, or not expressed in immunohistochemistry (IHC) protein expression data retrieved from the Human Protein Atlas (HPA). The minimized upper right image depicts the whole tissue section in each tissue microarray (TMA) slide. c Distribution of cytolytic genes within COAD and READ tumors. Gene set variation analysis (GSVA) signature scores for cytolytic index distinguished top quartile (orange) and bottom quartile (green) samples for cytolytic-high (CYT-high) and low (CYT-low) tumors, respectively. d Kaplan-Meier curve analysis of GZMA and PRF1 shows that high expression of both GZMA and PRF1 in colon (but not rectal) cancers, synergistically affects the patients' overall survival