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. Author manuscript; available in PMC: 2020 Jun 18.
Published in final edited form as: Acc Chem Res. 2019 May 28;52(6):1496–1506. doi: 10.1021/acs.accounts.9b00101

Figure 4.

Figure 4.

In vivo gene silencing mediated by iron oxide NP delivery of siRNA. (a) Timeline of tumor implantation and treatment. Two weeks after injection with HCC cells, mice received five daily injections of NPs. Luminescence imaging was initiated one day prior to the first NP injection. (B) Representative luminescence images of mice bearing HCC tumors. Untreated mice and mice treated with scramble siRNA served as controls. (c) Quantitative luminescence of mice from untreated and treated groups (n = 4). Luminescence was normalized to day 0 and the line graph presents the mean ± standard deviation. Arrows indicate NP injection time points. Adapted with permission from ref 30. Copyright 2015 WILEY-CVH Verlag GmbH & Co.