Table 2.
Comparisons by Age
| Characteristic | <60 yrs (N = 1716) |
60–75 yrs (N = 4012) |
>75 yrs (N = 1485) |
P trend^ |
|---|---|---|---|---|
| Age, years (mean ± s.d.) | 54.1 ± 4.5 | 67.4 ± 4.4 | 80.5 ± 3.7 | |
| Male sex | 1211 (71) | 2525 (63) | 701 (47) | <.001 |
| Race: | ||||
| White only | 1143 (67) | 2933 (73) | 1143 (77) | |
| Black only | 43(3) | 58(1) | 10(1) | |
| East Asian only | 410 (24) | 764(19) | 240 (16) | |
| Others (includes not reported/multiracial) | 120(7) | 258 (6) | 92 (6) | <.001 |
| BMI, kg/m2 (mean ± s.d.) | 27.9 ± 5.4 | 27.3 ± 5.0 | 26.3 ± 4.5 | <.001 |
| Weight, kg (mean ± s.d.) | 80.5 ± 17.3 | 76.6 ± 16.2 | 69.9 ± 14.5 | <.001 |
| Estimated glomerular filtration rate (eGFR), mL/min per 1.73 m2 | 88.1 ± 21.0 | 78.7 ± 19.3 | 67.5 ± 17.4 | <.001 |
| Medical history: | ||||
| Hypertension | 1344 (78) | 3005 (75) | 1237 (83) | 0.002 |
| Diabetes mellitus | 456 (27) | 1014 (25) | 335 (23) | 0.01 |
| Current tobacco use | 648 (38) | 760 (19) | 76 (5) | <.001 |
| Coronary artery disease | 79 (5) | 254 (6) | 140 (9) | <.001 |
| Heart failure | 65 (4) | 113 (3) | 60 (4) | 0.80 |
| Cancer | 43 (3) | 358 (9) | 219 (15) | <.001 |
| Bioprosthetic heart valve | 3 (0) | 12 (0) | 6 (0) | 0.23 |
| Prior stroke or TIA | 331 (19) | 625 (16) | 307 (21) | 0.44 |
| Global region: | ||||
| U.S.A. and Canada | 251 (15) | 502 (13) | 165 (11) | |
| Latin America | 177 (10) | 429 (11) | 140 (9) | |
| Western Europe | 595 (35) | 1672 (42) | 814 (55) | |
| Eastern Europe | 306 (18) | 681 (17) | 132 (9) | |
| East Asia | 387 (23) | 729 (18) | 234 (16) | <.001 |
| Qualifying stroke: | ||||
| Clinical TIA with imaging-confirmed infarction as qualifying event: | 96 (6) | 311 (8) | 114 (8) | 0.02 |
| Arterial territory of qualifying stroke: | ||||
| Anterior circulation | 1224 (71) | 2868 (71) | 1095 (74) | 0.14 |
| Posterior circulation | 538 (31) | 1280 (32) | 451 (30) | 0.58 |
| Location of qualifying stroke: | ||||
| Single Location: | ||||
| Cerebral hemisphere with cortical involvement | 828 (48) | 2276 (57) | 932 (63) | <.001 |
| Cerebral hemisphere, subcortical only | 461 (27) | 839 (21) | 218 (15) | <.001 |
| Brainstem only | 95 (6) | 191 (5) | 45 (3) | <.001 |
| Cerebellum only | 148 (9) | 302 (8) | 112 (8) | 0.23 |
| Multiple Locations: | 184 (11) | 403 (10) | 175 (12) | 0.38 |
| Chronic infarct on imaging (in addition to index stroke) | 528 (31) | 1278 (32) | 544 (37) | <.001 |
| Aspirin use prior to qualifying stroke | 216 (13) | 673 (17) | 358 (24) | <.001 |
| Treated with intravenous tPA for qualifying stroke | 271 (16) | 736 (18) | 248 (17) | 0.42 |
| Treated with endovascular intervention for qualifying stroke | 69 (4) | 174 (4) | 57 (4) | 0.83 |
| NIHSS score at randomization (median, IQR) | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) | 1.0 (0.0, 2.0) | <.001 |
| Modified Rankin Scale (mRS) at randomization: | ||||
| mRS 0 or 1 | 1091 (64) | 2704 (67) | 875 (59) | |
| mRS 2 | 436 (25) | 877 (22) | 360 (24) | |
| mRS ≥3 | 189 (11) | 431 (11) | 250 (17) | <.001 |
| MoCA score at randomization (median, IQR) | 26.0 (22.0, 28.0) | 25.0 (21.0, 27.0) | 22.0 (18.0, 26.0) | <.001 |
| Time from qualifying stroke to randomization, days (median, IQR) | 35.0 (14.0, 87.5) | 37.0 (15.0, 90.0) | 36.0 (14.0, 86.0) | 0.42 |
Abbreviations: BMI, body mass index; IQR, interquartile range; MoCA, Montreal Cognitive Assessment; NIHSS, National Institutes of Health Stroke Scale; SD, standard deviation; TIA, transient ischemic attack; tPA, tissue plasminogen activator.