Fig. 5. Tangent modulus at physiologic stress.
The tangent modulus of sham non-infarcted hearts, saline-injected infarcted hearts (PBS), and therapy-treated infarcted hearts (ESA) is calculated at 19.1 kPa, the estimated pathophysiologic wall stress of a rat left ventricle (LV) 4 weeks after myocardial infarction. ** indicates p-value < 0.01. *** indicates p-value < 0.001. Hearts in the ESA group were significantly less stiff than hearts in the PBS group, and had similar modulus as hearts in the sham group.