Table 1.

Summary of key molecular pathways mediating apoptotic cell phagocytosis. Examples of molecules mediating either direct or indirect (via bridging molecules) recognition of apoptotic cells, together with putative signaling mechanisms that are triggered (Savill et al., 1990; Savill et al., 1992; Stitt et al., 1995; Mevorach et al., 1998; Taylor et al., 2000; Albert et al., 2000; Scott et al., 2001; Stuart et al., 2007; Park et al., 2007; Rothlin et al., 2007; Park et al., 2008; Tibrewal et al., 2008; Païdassi et al., 2008; Park et al., 2009; Nakahashi-Oda et al., 2012; Ramirez-Ortiz et al., 2013; Kourtzelis et al., 2019).

Receptor	Ligand	Signaling
Direct recognition
BAI-1	PtdSer	GPCR – DOCK180, ELMO, Rac-1 (Park et al., 2007)
TIM-4	PtdSer	Indirect via integrins (Park et al., 2009)
CD300	PtdSer	ITIM (Nakahashi-Oda et al., 2012)
Stabilin-2/MEGF-10	PtdSer	via GULP (Park et al., 2008)
Indirect recognition
MER	PROS1, GAS6 (Stitt et al., 1995)	Autophosphorylation, Akt, PLCγ2, FAK, Rac-1 (Tibrewal et al., 2008)
AXL	Gas6	IFNAR, STAT1, SOCS1/3 (Rothlin et al., 2007)
SCARF (Ramirez-Ortiz et al., 2013)	C1q (Païdassi et al., 2008)
Integrin αMβ2 (Mevorach et al., 1998)	C1q
Integrin αvβ5	MFG-E8 Del-1	FAK, DOCK180, Rac-1 (Akakura et al., 2004; Albert et al., 2000)
Integrin αvβ3	MFG-E8 Del-1 TSP-1	CRKII, DOCK180, Rac-1 (Hanayama et al., 2002; Savill et al., 1990; Savill et al., 1992)
CD36	TSP-1	Fyn, Pyk2 (Stuart et al., 2007)

(Savill et al., 1990; Savill et al., 1992; Stitt et al., 1995; Mevorach et al., 1998; Albert et al., 2000; Hanayama et al., 2002; Akakura et al., 2004; Park et al., 2007; Rothlin et al., 2007; Stuart et al., 2007; Païdassi et al., 2008; Park et al., 2008; Tibrewal et al., 2008; Park et al., 2009; Nakahashi-Oda et al., 2012; Ramirez-Ortiz et al., 2013)