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. 2019 Aug 4;2019:1486232. doi: 10.1155/2019/1486232

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Copyright © 2019 H. Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BAY 11-7085 treatment on the barrier function examined by ECIS and FITC-dextran permeability assay. Irradiation with 5 Gy significantly reduces the resistance in HUVECs when compared to the nonirradiated (0 Gy) group (a). The treatment with BAY 11-7085 at 2.5 μM partially blocked the decreased resistance in HUVECs caused by 5 Gy gamma irradiation, while the treatment alone did not have any significant effects in HUVECs without gamma radiation exposure (a). The fluoresce intensity of FITC-labelled dextrans (4 kDa) was significantly higher after 5 Gy gamma irradiation, and the treatment of BAY 11-7085 partially inhibited this increase (b). ^∗p < 0.05 vs. 0 Gy; ^#p < 0.05 vs. 5 Gy.