Table 2.
Small molecules that potentially reverse dysregulation of expression profile in lymphatic metastasis and PCa samples, respectively.
| CMAP drug name | Enrichment score | Mean score | P value |
|---|---|---|---|
| Non-LNM compared with LNM samples | |||
| Geldanamycin | -0.983 | -0.806 | 0.001 |
| Econazole | -0.956 | -0.804 | 0.002 |
| 6-Bromoindirubin-3′-oxime | -0.953 | -0.616 | 0.005 |
| Triamterene | -0.942 | -0.449 | 0.007 |
| Rilmenidine | -0.941 | -0.341 | 0.007 |
| Fludrocortisone | -0.918 | -0.388 | 0.014 |
| Mimosine | -0.909 | -0.373 | 0.017 |
| Tocainide | -0.896 | -0.384 | 0.022 |
| Ethoxyquin | -0.871 | -0.330 | 0.033 |
| Acenocoumarol | -0.812 | -0.441 | 0.049 |
| Normal tissue compared with PCa tissue | |||
| Econazole | -0.972 | -0.784 | 0.002 |
| Rilmenidine | -0.968 | -0.719 | 0.002 |
| 6-Bromoindirubin-3′-oxime | -0.878 | -0.529 | 0.004 |
| Diphenhydramine | -0.957 | -0.446 | 0.004 |
| Naftidrofuryl | -0.955 | -0.336 | 0.004 |
| PF-00539758-00 | -0.952 | -0.343 | 0.005 |
| Meteneprost | -0.950 | -0.408 | 0.005 |
| Quipazine | -0.947 | -0.397 | 0.006 |
| Benzamil | -0.841 | -0.467 | 0.008 |
| Azacyclonol | -0.933 | -0.368 | 0.009 |