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. 2019 Aug 13;10:877. doi: 10.3389/fneur.2019.00877

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Copyright © 2019 Saaybi, AlArab, Hannoun, Saade, Tutunji, Zeeni, Shbarou, Hourani and Boustany.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) TBSS analysis of major WM tracts illustrating significant regional fractional anisotropy (FA) decreases (>5%, p < 0.05) shown in red between pre-therapy ASD patients(G1) and control subjects in the left (L) and right (R) uncinate fasciculus, left and right inferior fronto-occipital fasciculus, right superior longitudinal fasciculus, forceps minor, left superior fronto-occipital fasciculus left and right anterior corona radiata, left external capsule, and right superior longitudinal fasciculus. (B) TBSS analysis of major WM tracts, illustrating regional radial diffusivity (RD) increases (>5%, p < 0.05) shown in blue between G1 and control patients in forceps minor, left superior fronto-occipital fasciculus, right inferior fronto-occipital fasciculus, left and right uncinate fasciculi, right superior longitudinal fasciculus (temporal part), right superior longitudinal fasciculus, left and right anterior corona radiata, and left external capsule. (C) TBSS analysis of the major WM tracts, illustrating regional fractional anisotropy (FA) increases (>5%, p < 0.05) shown in blue between G1 and G2 patients in left and right superior longitudinal fasciculi, left and right inferior fronto-occipital fasciculi, left and right corticospinal tracts, left and right anterior thalamic radiations, forceps major, forceps minor, left external capsule, left and right anterior and posterior corona radiata, right sagittal stratum, left and right posterior and anterior limbs of internal capsule, left cerebral peduncle, right fornix cres, stria terminalis, splenium, genu, and body of the corpus callosum.