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. 2019 Aug 5;2019:8535273. doi: 10.1155/2019/8535273

Figure 1.

Figure 1

BKT130 reduces CD11b+ cell migration to the laser-treated area. Rat retinal flat mounts were prepared 10 days following laser injury and intravitreal injections. Flat mounts were observed using a confocal laser scanning system. CD11b-positive cells were observed in the center of the laser-treated areas (a). Each laser-treated area was observed in a 40x lens, and the macrophages (magenta) were counted (b–e). The eyes injected with BKT130, aflibercept, or BKT130+aflibercept demonstrated less CD11b-positive cells ((d) and (e), respectively) compared with PBS-injected eyes (b). A comparison between the amounts of cells found in laser-treated areas in each group is provided in (f). The Y-axis presents the mean (±SEM) number of CD11b+ cells found in each laser-treated area, in either BKT130 (number of laser burns = 19), aflibercept (n = 25 laser injury areas), BKT130+aflibercept (n = 41), or control PBS-injected group (n = 24). ∗ P < 0.05 and ∗∗ P < 0.005.