Figure 2.

In vivo assessment of BKT130's effect in a rodent model of LI-CNV. BKT130 was injected intravitreally in a rat model of LI-CNV (n = 9 eyes). The eyes injected with PBS served as a negative control (n = 10), while intravitreal injections of aflibercept served as the positive control (n = 8). BKT130 was also injected with aflibercept to assess an additive effect (n = 8). CNV was identified and quantified using a fluorescent microscope in isolectin-stained RPE-choroid flat mounts (a–d). Each laser treated area was observed in a 20x lens and the whole flat mount in 4x lens. The CNV area was measured and compared between treatments and between PBS-injected eyes (e). The Y-axis presents the averaged (±SEM) CNV area (mm²) of treated and PBS-injected control eyes. ^∗∗ P < 0.005 and ^∗∗∗ P < 0.0005.