Table 2.

Univariate analysis of overall, cancer-specific, and progression-free survival.

	OS		CSS		PFS
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
CASZ1
Low vs. high	0.441 (0.328-0.593)	<0.001	0.363 (0.254-0.518)	<0.001	0.456 (0.342-0.608)	<0.001
Age (years)
≤55 vs. >55	3.242 (2.383-4.410)	<0.001	2.290 (1.596-3.285)	<0.001	1.852 (1.420-2.415)	<0.001
Gender
Male vs. female	1.160 (0.845-1.594)	0.359	1.149 (0.771-1.714)	0.494	1.0800 (0.800-1.457)	0.617
WHO/ISUP grade
1, 2 vs. 3, 4	2.650 (1.994-3.520)	<0.001	6.093 (3.892-9.538)	<0.001	3.034 (2.295-4.012)	<0.001
T category
T1, T2 vs. T3, T4	3.413 (2.597-4.485)	<0.001	6.012 (4.298-8.4.9)	<0.001	4.822 (3.715-6.259)	<0.001
N category
N0/Nx vs. N1	8.100 (4.596-14.278)	<0.001	10.984 (6.026-20.018)	<0.001	6.655 (3.710-11.938)	<0.001
M category
M0 vs. M1	11.088 (8.098-15.182)	<0.001	19.696 (13.821-28.067)	<0.001	15.998 (11.726-21.826)	<0.001

OS: overall survival; CSS: cancer-specific survival; PFS: progression-free survival; HR: hazard ratio; CI: confidence interval.