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. 2019 Aug 13;10:992. doi: 10.3389/fphys.2019.00992

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Copyright © 2019 Hwang, Baldo, Rodriguez, Faggioni and Knollmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flecainide inhibition of spontaneous Ca releases (SCRs) exhibited a significant lag time in intact cardiomyocytes. (A) Experimental protocol in field-stimulated myocytes. (B) Exposure time-dependent effects of flecainide (FLEC). (C) Concentration-dependent effects of flecainide on the rate of Ca²⁺ waves after acute isoproterenol exposure (1 μM) in intact myocytes. IC₅₀ values (mean ± SEM) were obtained by fitting the values to a Boltzmann function. ^*p < 0.05 vs. VEH. n = 22–33 myocytes per group.