FIGURE 3.

Effect of flecainide on intracellular Ca²⁺ handling of cardiomyocytes isolated from RyR2^R4496C+/– mice. (A) Diastolic intracellular Ca²⁺. (B) The amplitude of caffeine-induced Ca²⁺ transients (ΔF_ratio) was used as estimates of sarcoplasmic reticulum (SR) Ca²⁺ content. Incidence (C) and frequency (D) of SCRs. The incidence of SCRs was analyzed by Fisher exact test and the frequency of SCRs was compared by non-parametric Mann–Whitney U test. †p < 0.05 vs. 2 mM [Ca²⁺] VEH, ‡ p < 0.05 vs. 3 mM [Ca²⁺] VEH, ^*p < 0.05 vs. each VEH, n = 20–33 myocytes per group.