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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Ultrasound Med Biol. 2019 Apr 16;45(7):1762–1776. doi: 10.1016/j.ultrasmedbio.2019.02.004

Figure 1: (Color online) Sonication strategy.

Figure 1:

Colorectal adenocarcinoma (Caco-2) cells were cultured on permeable Transwell supports. Phase-change contrast agents (PCCAs) and dextran were added to the donor chamber before sonication and samples were collected from the receiving compartment over the following 72 hours post-ultrasound treatment. The twelve-well culture plates were positioned in a custom water bath and coupled to the 37°C water below before treatment. A lid with circular holes was used to align the ultrasound transducer in the center of each well at a consistent height above the cells.