Table 3.
Risk of medical intensive care unit (MICU) admission by HIV, hepatitis C virus (HCV), alcohol-related diagnosis (ARD), and calendar era, n=155,550
| All groups | ||||||
|---|---|---|---|---|---|---|
| Crude | Adjusted | Adjusted | Adjusted | |||
| Exposure group | 1997–2014 | 1997–2014 | 1997–2009 | 2010–2014 | ||
| HIV+ | ARD+ | HCV+ | 2.26 (1.17–2.34) | 2.36 (2.26–2.46) | 2.29 (2.17–2.42) | 2.40 (2.23–2.58) |
| HCV− | 1.89 (1.83–1.95) | 2.14 (2.06–2.22) | 2.34 (2.24–2.44) | 1.75 (1.64–1.86) | ||
| ARD− | HCV+ | 1.64 (1.58–1.71) | 1.74 (1.67–1.81) | 1.66 (1.58–1.75) | 1.94 (1.80–2.09) | |
| HCV− | 1.38 (1.35–1.41) | 1.46 (1.43–1.50) | 1.61 (1.56–1.65) | 1.21 (1.16–1.27) | ||
| HIV− | ARD+ | HCV+ | 1.72 (1.66–1.79) | 1.80 (1.73–1.88) | 1.69 (1.60–1.78) | 1.91 (1.78–2.04) |
| HCV− | 1.37 (1.33–1.40) | 1.46 (1.42–1.50) | 1.46 (1.41–1.50) | 1.44 (1.38–1.50) | ||
| ARD− | HCV+ | 1.25 (1.20–1.31) | 1.33 (1.27–1.39) | 1.22 (1.16–1.29) | 1.54 (1.43–1.67) | |
| HCV− | ref | ref | ref | ref | ||
| By HIV | ||||||
| HIV+ | HCV+/ARD+ | 1.64 (1.57–1.70) | 1.62 (1.55–1.70) | 1.45 (1.37–1.53) | 1.98 (1.83–2.14) | |
| HCV+/ARD− | 1.19 (1.14–1.24) | 1.19 (1.14–1.24) | 1.04 (0.99–1.09) | 1.60 (1.48–1.73) | ||
| HCV−/ARD+ | 1.37 (1.32–1.42) | 1.33 (1.28–1.38) | 1.33 (1.28–1.39) | 1.29 (1.21–1.38) | ||
| HCV−/ARD− | ref | ref | ref | ref | ||
| HIV− | HCV+/ARD+ | 1.72 (1.66–1.79) | 1.76 (1.69–1.84) | 1.65 (1.56–1.74) | 1.88 (1.75–2.02) | |
| HCV+/ARD− | 1.25 (1.20–1.31) | 1.29 (1.23–1.35) | 1.19 (1.12–1.26) | 1.52 (1.41–1.65) | ||
| HCV−/ARD+ | 1.37 (1.33–1.41) | 1.47 (1.42–1.52) | 1.49 (1.43–1.55) | 1.36 (1.29–1.44) | ||
| HCV−/ARD− | ref | ref | ref | ref | ||
| By HCV | ||||||
| HCV+ | HIV+/ARD+ | 1.80 (1.69–1.92) | 1.78 (1.66–1.90) | 1.88 (1.73–2.04) | 1.55 (1.39–1.74) | |
| HIV+/ARD− | 1.31 (1.26–1.37) | 1.31 (1.25–1.37) | 1.36 (1.29–1.43) | 1.26 (1.17–1.35) | ||
| HIV−/ARD+ | 1.37 (1.32–1.43) | 1.36 (1.30–1.42) | 1.38 (1.31–1.46) | 1.24 (1.14–1.34) | ||
| HIV−/ARD− | ref | ref | ref | ref | ||
| HCV− | HIV+/ARD+ | 1.89 (1.83–1.95) | 2.14 (2.06–2.22) | 2.34 (2.24–2.44) | 1.75 (1.64–1.86) | |
| HIV+/ARD− | 1.38 (1.35–1.41) | 1.46 (1.43–1.50) | 1.60 (1.56–1.65) | 1.21 (1.16–1.27) | ||
| HIV−/ARD+ | 1.37 (1.33–1.40) | 1.46 (1.42–1.50) | 1.46 (1.41–1.50) | 1.44 (1.38–1.50) | ||
| HIV−/ARD− | ref | ref | ref | ref | ||
Notes: reported as RR (95% confidence intervals); models adjusted for baseline age, comorbidity (psychiatric disorders, hypertension, drug use-related diagnoses, diabetes, cardiovascular disease, anemia, chronic obstructive pulmonary disorder, non-AIDS cancers, renal insufficiency, chronic hepatitis B, and liver diseases), and calendar year
Abbreviations: HIV - human immunodeficiency virus; RR - rate ratio; CI - confidence interval; ref - referent group