Table 1.

Study design and outcomes

Aim	Design/method	Outcome measures/outputs	When collected
1	Controlled pre-post study involving retrospective review of medical records	Rates of potential DDIs Rates of clinically relevant DDIs Rates of patient harm	Before and after EMM
2	Human factors evaluation—observations and interviews with prescribers	Alert usability and acceptability, barriers and facilitators to optimal use of alerts	After EMM
3	Analysis of alert data extracted from EMM systems	Alert burden (alerts/patient; alerts/order; alerts/prescriber)	After EMM
4	Analysis of patient and medication information collected during retrospective review and extracted from clinical information systems	Algorithms which predict clinically relevant DDIs	After EMM

DDI, drug–drug interaction; EMM, electronic medication management.