. 2019 Aug 10;9(8):e029798. doi: 10.1136/bmjopen-2019-029798

Table 1.

Characteristics and outcomes of previous trials comparing non-invasive ventilation to oxygen therapy in immunocompromised patients

Authors	Year	Setting	N=	Arms	Intubation rate (%)	In-ICU mortality rate (%)
Antonelli et al	2000	ICU, monocentre	20	O₂	70	50
Antonelli et al	2000	ICU, monocentre	20	NIV	20	20
Hilbert et al	2001	ICU, monocentre	26	O₂	77	69
Hilbert et al	2001	ICU, monocentre	26	NIV	46	38
Lemiale et al	2015	ICU, multicentre	183	O₂	45	25
Lemiale et al	2015	ICU, multicentre	191	NIV	38	21
Squadrone et al	2010	Ward, monocentre	20	O₂	40	75*
Squadrone et al	2010	Ward, monocentre	20	CPAP	10	15*
Frat et al†	2016	ICU, multicentre	30	O₂	43	20
			26	NIV	65	42
			26	HFOT	31	15

Outcomes of patients in the control arm are displayed in italics.

*Hospital mortality (ICU mortality was not indicated in the article).

†Post hoc analysis of a randomised trial.

CPAP, continuous positive airway pressure; HFOT, high-flow nasal oxygen therapy;ICU, intensive care unit; NIV, non-invasive ventilation; O₂, oxygen therapy.