Table 1. Baseline characteristics and non-invasive scores in the presence or absence of clinically significant portal hypertension (HVPG ≥10 mmHg).
| All (n = 19) |
HVPG <10 mmHg (n = 10) | HVPG ≥10 mmHg (n = 9) | P value | |
|---|---|---|---|---|
| Age (years) | 57 (47–68) | 64 (50–74) | 57 (45–63) | 0.211 |
| Male (%) | 15 (79%) | 9 (90%) | 6 (67%) | 0.213 |
| BMI (kg/m2) | 30.0 (24.2–32.3) | 29.0 (23.9–33.4) | 30.0 (24.6–32.2) | 0.968 |
| Cirrhosis (%) | 10 (53%) | 3 (30%) | 7 (78%) | 0.037 |
| Ishak stage (0–6) | 5 (1–6) | 1 (1–2) | 6 (5–6) | 0.028 |
| Aetiology | 0.151* | |||
| NAFLD (%) | 9 (47%) | 4 (40%) | 4 (44%) | |
| ASH (%) | 5 (26%) | 1 (10%) | 3 (33%) | |
| Viral hepatitis (%) | 4 (21%) | 1 (10%) | 2 (22%) | |
| Other (%) | 2 (11%) | 4 (40%) | 2 (22%) | |
| Bilirubin (μmol/l) | 12 (10–22) | 12 (8–19) | 13 (11–31) | 0.447 |
| ALT (IU/l) | 44 (22–71) | 42 (23–92) | 49 (20–68) | 0.604 |
| ALP (IU/l) | 188 (147–236) | 175 (113–247) | 205 (152–275) | 0.447 |
| Albumin (g/l) | 41 (37–46) | 43 (38–46) | 40 (33–44) | 0.315 |
| AST (IU/l) | 39 (32–76) | 35 (26–70) | 57 (37–78) | 0.200 |
| GGT (IU/l) | 93 (40–277) | 57 (25–226) | 170 (60–279) | 0.370 |
| Platelets (x109/l) | 133 (112–216) | 135 (121–242) | 113 (98–202) | 0.211 |
| PT (s) | 14.4 (13.1–16.6) | 13.5 (12.1–15.1) | 14.9 (14.4–17.3) | 0.035 |
| Liver stiffness (kPa) | 21.3 (8.7–36.4) | 11.9 (8.3–37.3) | 35.1 (33.0–36.6) | 0.148 |
| AST/ALT ratio | 1.09 (0.84–1.65) | 0.88 (0.68–1.07) | 1.39 (1.12–2.08) | 0.021 |
| APRI | 0.72 (0.53–1.21 | 0.64 (0.52–0.75) | 1.02 (0.71–1.57) | 0.114 |
| FIB-4 | 3.17 (1.84–4.01) | 2.21 (1.37–3.51) | 3.65 (2.41–5.46) | 0.167 |
| Child Pugh A | 15 (79%) | 8 (80%) | 7 (78%) | ns |
| Child Pugh B | 4 (21%) | 2 (20%) | 2 (22%) | |
| Child Pugh C | 0 | 0 | 0 | |
| Ascites present | 2 (11%) | 1 (10%) | 1 (11%) | ns |
| MR data | ||||
| Spleen cT1 (ms) | 1319 (1181–1414) | 1212 (1169–1318) | 1414 (1376–1448) | 0.001 |
| Liver cT1 (ms) | 942 (867–1122) | 874 (837–996) | 1104 (938–1227) | 0.027 |
| Liver fat (%) | 4.9 (1.3–13.7) | 5.1 (1.3–13.4) | 2.3 (1.4–15.4) | 0.667 |
All data given as median (IQR) or frequency (%).
Abbreviations: HVPG, hepatic vein pressure gradient; BMI, body mass index; NAFLD, non-alcohol-related fatty liver disease; ASH, alcoholic steatohepatitis; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; GGT, gamma glutamyl transferase; PT, prothrombin time; APRI, AST to platelet ratio index; FIB-4, Fibrosis 4; ns, not significant
*Chi-squared test p value for the overall difference in liver disease aetiologies between groups